Zoloft (Sertraline) 50mgZoloft (Sertraline) 50mgZoloft (Sertraline) 50mg

Zoloft (Sertraline) 50mg

Active ingredient:  Sertraline

 Pfizer
€1.73 / pill
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Zoloft (Sertraline) 50mg is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

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General information

Zoloft (Sertraline) 50mg is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

ZOLOFT may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. It may also reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, and checking) that interfere with daily living. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.

Directions

How should I take Zoloft?

Take Zoloft (Sertraline) exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Zoloft (Sertraline) may be taken with or without food. Try to take the medicine at the same time each day. Zoloft can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Zoloft. It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Do not stop using Zoloft suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Sertraline Dosage

Usual Adult Dose for Depression

  • Initial dose: 50 mg orally once a day
  • Maintenance Dose: 50 to 200 mg orally once a day

Usual Adult Dose for Obsessive Compulsive Disorder

  • Initial dose: 50 mg orally once a day
  • Maintenance Dose: 50 to 200 mg orally once a day

Usual Adult Dose for Panic Disorder

  • Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
  • Maintenance dose: 50 to 200 mg orally once a day

Usual Adult Dose for Post Traumatic Stress Disorder

  • Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
  • Maintenance dose: 50 to 200 mg orally once a day

Usual Adult Dose for Social Anxiety Disorder

  • Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
  • Maintenance dose: 50 to 200 mg orally once a day

Usual Adult Dose for Premenstrual Dysphoric Disorder

Continuous regimen:

  • Initial dose: 50 mg orally once a day during the menstrual cycle
  • Maintenance dose: 50 to 150 mg orally once a day during the menstrual cycle

Cyclic regimen:

  • Initial dose: 50 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycle
  • Maintenance dose: 50 to 100 mg orally once a day

Usual Pediatric Dose for Obsessive Compulsive Disorder

6 to 12 years:

  • Initial dose: 25 mg orally once a day
  • Maintenance dose: 25 to 200 mg orally once a day

13 to 17 years:

  • Initial dose: 50 mg orally once a day
  • Maintenance dose: 50 to 200 mg orally once a day

Comments:

  • The dose may be increased at intervals of at least one week.
  • The potential risks versus clinical need should be assessed prior to using this drug in children and adolescents.
  • Treatment of OCD

Possible side effect

Get emergency medical help if you have signs of an allergic reaction to Zoloft (Sertraline) 50mg: skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a seizure (convulsions);
  • blurred vision, tunnel vision, eye pain or swelling;
  • low levels of sodium in the body - headache, confusion, memory problems, severe weakness, feeling unsteady; or
  • manic episodes - racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Zoloft (Sertraline) 50mg side effects may include:

  • drowsiness, tiredness, feeling dizziness, anxious or agitated;
  • indigestion, nausea, diarrhea, loss of appetite;
  • sweating;
  • tremors or shaking;
  • sleep problems (insomnia); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

Less Common or Rare

  • Aggressive reaction
  • breast tenderness or enlargement
  • confusion
  • convulsions
  • diarrhea
  • drowsiness
  • dryness of the mouth
  • fast talking and excited feelings or actions that are out of control
  • fever
  • inability to sit still
  • increase in body movements
  • increased sweating
  • increased thirst
  • lack of energy
  • loss of bladder control
  • mood or behavior changes
  • muscle spasm or jerking of all extremities
  • nosebleeds
  • overactive reflexes
  • racing heartbeat
  • red or purple spots on the skin
  • restlessness
  • shivering
  • skin rash, hives, or itching
  • sudden loss of consciousness
  • unusual or sudden body or facial movements or postures
  • unusual secretion of milk (in females)

Some side effects of sertraline may occur that usually do not need medical attention.

Zoloft (Sertraline) Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: pimozide, other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, "blood thinners" such as warfarin/dabigatran).

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including other SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as Alprazolam, Diazepam, Zolpidem), muscle relaxants, and opioid pain or cough relievers (such as Codeine, hydrocodone).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise.

This medication may interfere with certain medical/lab tests (including brain scan for Parkinson's disease), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Contraindications

ZOLOFT (Sertraline) 50mg is contraindicated in patients:

  • Taking, or within 14 days of stopping MAOIs (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome
  • Taking pimozide
  • With known hypersensitivity to sertraline (eg, anaphylaxis, angioedema)

To make sure Zoloft (Sertraline) 50mg is safe for you, tell your doctor if you have ever had:

  • heart disease, high blood pressure, or a stroke;
  • liver or kidney disease;
  • a seizure;
  • bleeding problems, or if you take warfarin (Coumadin, Jantoven);
  • bipolar disorder (manic depression); or
  • low levels of sodium in your blood.

Some medicines can interact with sertraline and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, other antidepressants, or medicine for mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking Zoloft (Sertraline) 50mg during pregnancy without your doctor's advice.

It is not known whether sertraline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give Zoloft (Sertraline) 50mg to anyone younger than 18 years old without the advice of a doctor. Zoloft (Sertraline) 50mg is FDA-approved for children with obsessive-compulsive disorder (OCD). It is not approved for treating depression in children.

In addition to the contraindications for all ZOLOFT formulations listed above, Zoloft (Sertraline) 50mg oral solution is contraindicated in patients taking disulfiram. ZOLOFT oral solution contains alcohol, and concomitant use of ZOLOFT and disulfiram may result in a disulfiram-alcohol reaction.

Precautions

Before taking Zoloft (Sertraline) 50mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex found in the medicine dropper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, bleeding problems, liver disease, seizure disorder, thyroid disease, personal or family history of glaucoma (angle-closure type).

Sertraline may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using sertraline, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using sertraline safely.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

The liquid form of this medication contains alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Some medications (such as metronidazole, disulfiram) can cause a serious reaction when combined with alcohol. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially bleeding, loss of coordination, or QT prolongation (see above). Loss of coordination can increase the risk of falling. Older adults may also be more likely to develop a type of salt imbalance (hyponatremia), especially if they are taking "water pills" (diuretics).

Children may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss. Monitor weight and height in children who are taking this drug.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated mental/mood problems (such as depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Storage

Store Zoloft (Sertraline) 50mg at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

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